Publications
Publications related to ArcDia technologies
TPX-technology – literature references
TPX-technology – downloadable posters
Timeresolved fluorescence technology – literature references
Timeresolved fluorescence technology – downloadable posters
TPX-technology literature references
Monographies
Koskinen, Janne O.
Two-photon excitation fluorometry in detection of infectious diseases
Annales Universitatis Turkuensis, Series A I, Part. 384
University of Turku, Ph.D. Thesis, ISBN 978-951-29-3695-3, ISSN 0082-7002, Turku, Finland 2008
Soini, Juhani T.
Development of instrumentation for single-step, multiplexed, microvolume bioaffinity assays
Annales Universitatis Turkuensis, Sarja A I, Part. 281
Department of Medical Physics and Chemistry, Institute of Biomedicine, University of Turku, Ph.D. Thesis, 166 pages, ISBN 951-29-2074-3, ISSN 0082-7002, Painosalama Oy, Turku, Finland 2002
Scientific publications
Hanna Smolander, Janne O. Koskinen*, Klaus Hedman, Raija Vainionpää, Niko J. Meltola, Aleksi E. Soini.
A novel antibody avidity methodology for rapid point-of-care serological diagnosis.
Journal of Virological Methods (2010a). Accepted. *Corresponding author.
Janne O. Koskinen, Teppo Stenholm, Jonne Vaarno, Jori Soukka, Niko J. Meltola, and Aleksi E. Soini. Development of a rapid assay methodology for antimicrobial susceptibility testing of Staphylococcus aureus.
Diagnostic Microbiology and Infectious Diseases (2008), 62(3):306-316.
Janne O. Koskinen, Raija Vainionpää, Niko J. Meltola, Pekka E. Hänninen, Aleksi E. Soini.
Rapid method for detection of influenza A and B virus antigens by use of a two-photon excitation assay technique and dry-chemistry reagents.
Journal of Clinical Microbiology (2007), 45(11):3581-3588.
Janne O. Koskinen, Jonne Vaarno, Raija Vainionpää, Aleksi E. Soini.
A Novel separation-free assay technique for serum antibodies using antibody bridging assay principle and two-photon excitation fluorometry.
Journal of Immunological Methods (2006), 309(1-2):11-24.
Janne O. Koskinen, Niko J. Meltola, Erkki Soini, Aleksi E. Soini.
A lab-on-a-chip compatible bioaffinity assay method for human α-fetoprotein.
Lab-on-a-Chip (2005), 5(12):1408-1411.
Janne O. Koskinen, Jonne Vaarno, Niko J. Meltola, Juhani T. Soini, Pekka E. Hänninen, Juhani Luotola, Matti E. Waris, Aleksi E. Soini.
Fluorescent nanoparticles as labels for immunometric assay of C-reactive protein using two-photon excitation assay technology.
Analytical Biochemistry. (2004), 328 (2):210-218.
Soini, JT; Waris ME; Hanninen, PE
Detection methods of microsphere based single-step bioaffinity and in-vitro diagnostics assays
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 34 (4): 763-770 MAR 2004
Meltola, NJ; Soini, AE; Hanninen, PE
Syntheses of novel dipyrrylmethene-BF2 dyes and their performance as labels in two-photon excited fluoroimmunoassay
JOURNAL OF FLUORESCENCE, 14 (2): 129-138 MAR 2004
Waris, ME; Meltola, NJ; Soini, JT; Soini, E; Peltola, OJ; Hanninen, PE
Two-photon excitation fluorometric measurement of homogeneous microparticle immunoassay for C-reactive protein
ANALYTICAL BIOCHEMISTRY, 309 (1): 67-74 OCT 1 2002
Soini, JT; Soukka, JM; Soini, E; Hanninen, PE
Two-photon excitation microfluorometer for multiplexed single-step bioaffinity assays
REVIEW OF SCIENTIFIC INSTRUMENTS, 73 (7): 2680-2685 JUL 2002
Hanninen, P; Soini, A; Meltola, N; Soini, J; Soukka, J; Soini, E
A new microvolume technique for bioaffinity assays using two-photon excitation
NATURE BIOTECHNOLOGY, 18 (5): 548-550 MAY 2000
Soini, E; Meltola, NJ; Soini, AE; Soukka, J; Soini, JT; Hanninen, PE
Two-photon fluorescence excitation in detection of biomolecules
BIOCHEMICAL SOCIETY TRANSACTIONS, 28: 70-74 Part 2 FEB 2000
Oral presentations in scientific congresses
Koskinen JO, M. Söderlund-Venermo, K. Hedman, R. Österback, T. Heikkinen, M. Waris, T. Allander, R. Vainionpää, A.E. Soini.
Rapid one-step antigen detection method for human bocavirus.
19th European Congress of Clinical Microbiology and Infectious Diseases, Helsinki/Finland, 2009. Clinical Microbiology and Infection, Volume 15, Supplement 4, abstract O249. Oral presentation and abstract.
Koskinen JO, Vainionpää R, Waris M, Huovinen P, Hedman K, Saukkoriipi A, Ruuskanen O, Ruohola A, Soini AE.
Rapid multianalyte POC test to aid physicians in pathogen-specific diagnosis of respiratory infections.
25th Annual SSAC Meeting, September 18-21, 2008c, Copenhagen, Danmark. Oral presentation and abstract.
Koskinen JO, Vainionpää R, Waris M, Huovinen P, Hedman K, Saukkoriipi A, Ruuskanen O, Ruohola A, Soini AE.
Rapid Multianalyte Identification of Respiratory Tract Pathogens.
26th Annual ESPID Meeting, May 13-17, 2008, Graz, Austria. Oral poster-walk presentation and abstract.
Koskinen JO, Vainionpää R, Waris M, Huovinen P, Hedman K, Saukkoriipi A, and Soini AE.
A New Rapid Method for Multianalyte POC Testing of Respiratory Tract Infections.
Annual meeting and congress of the European Society for Clinical Virology 2008, Saariselkä, Finland, 12-15 March, 2008. Oral presentation and abstract.
Koskinen JO, Stenholm T, Vaarno J, Soini AE.
New immunometric concept for rapid MRSA screening without pure-culture.
17th European Congress of Clinical Microbiology and Infectious Diseases, Munich/Germany, 31 March – 3 April 2007. Presentation and abstract. International Journal of Antimicrobial Agents, March 2007, Volume 29, Supplement 2, Page S63 / Clinical Microbiology and Infection, April 2007, Volume 13, Issue Supplement 1, abstract O302, Page S63.
Koskinen JO, Vainionpää R, Waris M, Susi P, Soini AE.
A rapid one-step immunoassay technique for multianalyte testing of respiratory pathogens.
Virology days 2007, 15.-16.2007, Oulu, Finland.
Posters
Koskinen JO, Järvinen E, Saukkoriipi A, Kaijalainen T, Soini AE.
Sensitivity and specificity of Group A streptococci and pneumococcus tests in a new rapid multianalyte respiratory infection test system.
27th Annual Meeting of the European Society for Paediatric Infectious Diseases, ESPID 2009, Brussels, Belgium, June 9-13, 2009. Abstract number 292, poster number 561.
Koskinen JO, Vainionpää R, Soini AE.
Novel multianalyte point-of-care test for pathogen-specific diagnosing of respiratory infections.
19th European Congress of Clinical Microbiology and Infectious Diseases, Helsinki/Finland, 2009. Clinical Microbiology and Infection, Volume 15, Supplement 4, abstract P1909.
Smolander HM, Koskinen JO, R. Vainionpää, K. Hedman, M. Lappalainen, E. Järvinen, N. Meltola, A.E. Soini.
The combination of antibody bridging and avidity index methodology for reliable and simple determination of infection phase.
19th European Congress of Clinical Microbiology and Infectious Diseases, Helsinki/Finland, 2009. Clinical Microbiology and Infection, Volume 15, Supplement 4, abstract P1908.
Koskinen JO, Meltola NJ, Hänninen PE, Soini AE.
Separation-free assay for thyroid-stimulating hormone with femtomolar sensitivity, pdf file (206kB). Euromedlab 2007, 3-7 June, 2007, Amsterdam, The Netherlands. Abstract, Clin. Chem. Lab. Med. 2007; 45, Special Supplement, pp S1-S473, abstract M228.
Jonne Vaarno, Emmi Ylikoski, Juhani T. Soini, Matti Waris, Riitta Lahesmaa and Pekka E. Hänninen
Detection of single nucleotide polymorphisms (SNP) using two-photon excitation based microparticle assay technology, (pdf file 1316kB)
8th International Workshop on Single Molecule Detection and Ultrasensitive Analysis in the Life Sciences, Adlershof, Berlin, Germany, 25-27.9.2002
Koskinen JO, Laitinen I, Luotola J, Lilius, E-M, Soini J, Waris M.
Seasonal variation of CRP studied by a separation-free microvolume ArcDiaTM TPX-assay technology, (pdf file 100kB)
EuroMedLab 2003, 1-5 June 2003, Barcelona, Spain. Abstract, Clin. Chem. Lab. Med. 41, S 275. Special supplement.
Marko Tirri, Marko J Mäenpää, Kenneth Rundt, Tiina Ojala, Mika Kettunen, Aleksi Soini, Niko Meltola, Jori Soukka, Matti Waris, Juhani Soini, Pekka Hänninen and Erkki Soini
A micro volume platereader for homogeneous bioaffinity assays based on two-photon fluorescence excitation, (pdf file 600kB)
7th International Workshop on Single Molecule Detection and Ultrasensitive Analysis in the Life Sciences, Adlershof, Berlin, Germany, 26-28.9.2001
Jori M Soukka, Juhani T Soini, Niko J Meltola, Aleksi E Soini, Matti E Waris, Erkki Soini and Pekka E Hänninen
A multiparametric separation free bioaffinity assay method based on two-photon fluorescence excitation, (pdf file 66kB)
European Science Foundation – Femtochemistry and Femtobiology (ULTRA): Ultrafast technology and advanced microscopy applications to intra-cellular and biomolecular dynamics, March 25-31, 2001, Institut d’Etudes Scientifiques, Cargáse, Corsica, France
Juhani T Soini, Niko J Meltola, Aleksi E Soini, Jori M Soukka, Matti E Waris, Kenneth Rundt, Erkki Soini and Pekka E Hänninen
A method for multiparametric separation free bioaffinity assays for microvolumes, (pdf file 61kB)
6th International Workshop on Single Molecule Detection and Ultrasensitive Analysis in the Life Sciences
Adlershof, Berlin, Germany, 27-29.9.2000
Pekka E Hänninen, Juhani T Soini, Niko J Meltola, Aleksi E Soini, Jori Soukka, Matti Waris and Erkki Soini
A micro volume bioaffinity assay based on two-photon excited fluorescence, (pdf file 46kB)
The 3rd Annual European Conference on Micro & Nanoscale Technology for the Biosciences
November 30 – December 2, 1999, Montreux, Switzerland
Juhani T Soini, Niko J Meltola, Aleksi E Soini, Jori M Soukka, Matti E Waris, Pekka E Hänninen and Erkki Soini
A micro volume bioaffinity assay based on two-photon excited fluorescence, (pdf file 41kB)
5th International Workshop on Single Molecule Detection and Ultrasensitive Analysis in the Life Sciences,
Adlershof, Berlin, Germany, 29.9-1.10.1999
Time-resolved phosphorescence technology literature references
Monographies
Soini, Aleksi E.
Monosubstituted phosphorescent metalloporphyrin labeling reagents – syntheses and applications in bioanalysis
Annales Universitatis Turkuensis, Sarja A I, Part. 306
Department of Medical Physics and Chemistry, Institute of Biomedicine, University of Turku,
Ph.D. Thesis, ISBN 951-29-2509-5, ISSN 0082-7002,Painosalama Oy, Turku, Finland 2002
Scientific publications
Soini, AE; Kuusisto, A; Meltola, NJ; Soini, E; Seveus, L
A new technique for multiparameter imaging microscopy: Use of long decay time photoluminescent labels enables multiple color immunocytochemistry with low channel-to-channel crosstalk
MICROSCOPY RESEARCH AND TECHNIQUE, 62 (5): 396-407 DEC 1 2003
Burke, M; O’Sullivan, PJ; Soini, AE; Berney, H; Papkovsky, DB
Evaluation of the phosphorescent palladium(II)-coproporphyrin labels in separation-free hybridization assays
ANALYTICAL BIOCHEMISTRY, 320 (2): 273-280 SEP 15 2003
Soini, AE; Yashunsky, DV; Meltola, NJ; Ponomarev, GV
Influence of linker unit on performance of palladium(II) coproporphyrin labelling reagent and its bioconjugates
LUMINESCENCE, 18 (3): 182-192 MAY-JUN 2003
Hynes, J; Floyd, S; Soini, AE; O’Connor, R; Papkovsky, DB
Fluorescence-based cell viability screening assays using water-soluble oxygen probes
JOURNAL OF BIOMOLECULAR SCREENING, 8 (3): 264-272 JUN 2003
Koskelin, MM; Soini, AE; Meltola, NJ; Ponomarev, GV
Phosphorescent labeling reagents of platinum(II) and palladium(II) coproporphyrin-II. Preparation and performance characteristics
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 6 (7-8): 533-543 2002
O’Riordan, TC; Soini, AE; Soini, JT; Papkovsky, DB
Performance evaluation of the phosphorescent porphyrin label: Solid-phase immunoassay of alpha-fetoprotein
ANALYTICAL CHEMISTRY, 74 (22): 5845-5850 NOV 15 2002
O’Sullivan, PJ; Burke, M; Soini, AE; Papkovsky, DB
Synthesis and evaluation of phosphorescent oligonucleotide probes for hybridisation assays
NUCLEIC ACIDS RESEARCH, 30 (21): art. no.-e114 NOV 1 2002
Soini, AE; Seveus, L; Meltola, NJ; Papkovsky, DB; Soini, E
Phosphorescent metalloporphyrins as labels in time-resolved luminescence microscopy: Effect of mounting on emission intensity
MICROSCOPY RESEARCH AND TECHNIQUE, 58 (2): 125-131 JUL 15 2002
Soini, AE; Yashunsky, DV; Meltola, NJ; Ponomarev, GV
Preparation of monofunctional and phosphorescent palladium(II) and platinum(II) coproporphyrin labeling reagents
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 5 (10): 735-741 OCT 2001
O’Riordan, TC; Soini, AE; Papkovsky, DB
Monofunctional derivatives of coproporphyrins for phosphorescent labeling of proteins and binding assays
ANALYTICAL BIOCHEMISTRY, 290 (2): 366-375 MAR 15 2001
Posters
Aleksi Soini and Niko Meltola
Monosubstituted Reactive Derivatives Metalloporphyrins for Phosphorescent Labeling of Biomolecules, (pdf file 131kB)
7th Conference on Methods and Applications of Fluorescence: Spectroscopy, Imaging and Probes, Amsterdam, The Netherlands, 16-19 September 2001 Go up
Posters are in Adobe AcrobatTM PDF-format, and can be viewed using the Adobe Acrobat Reader